分子量：Calculated MW: 130kDa/134kDa
Observed MW: 130kDa

细胞定位：Cell membrane, Single-pass type I membrane protein

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:50 - 1:200

总结：This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.