产品概述：Recombinant protein of human E1A binding protein p300 (EP300), residues 1066-1707, with C-terminal DDK tag, expressed in sf9 cells

蛋白长度：A DNA sequence from GoldORF clone, [GH52463V], encoding E1A binding domain(Tyr1066-Lys1707)of human EP300

表达系统：Sf9

种属：Human

标签类型：C-DDK

分子量：75 kDa

通用名：EP300

总结：This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

形式：Liquid

浓度：>50 ug/mL as determined by microplate BCA method

纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining

储存溶液：50mM Tris-HCl pH8.0, 150mM NaCl, 20% glycerol

别名：KAT3B; MKHK2; p300; RSTS2