分子量：Calculated MW: 108kDa/112kDa
Observed MW: 113kDa

细胞定位：Endoplasmic reticulum lumen, Membrane, Single-pass type I membrane protein

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:100

总结：This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.