Mxra8 (NM_024263) Mouse Recombinant Protein-蛋白质/抗原/多肽-试剂-生物在线
安诺伦(北京)生物科技有限公司
Mxra8 (NM_024263) Mouse Recombinant Protein

Mxra8 (NM_024263) Mouse Recombinant Protein

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产品名称: Mxra8 (NM_024263) Mouse Recombinant Protein

英文名称: Mxra8 (NM_024263) Mouse Recombinant Protein

产品编号: PM44235M5

产品价格: 0

产品产地: 美国

品牌商标: Leading Biology

更新时间: null

使用范围: null

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产品概述:Purified recombinant protein of Mouse matrix-remodelling associated 8 (Mxra8), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

蛋白长度:A DNA sequence from Mouse cDNA ORF Clone, [GM45580V], encoding Mouse full-length Mxra8.

表达系统:HEK293T

种属:Mouse

标签类型:C-MYC/DDK

分子量:50.2 kDa

通用名:Mxra8

总结:Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB/Swiss-Prot Function]

形式:Liquid

浓度:>50 ug/mL as determined by microplate BCA method

纯度:> 80% as determined by SDS-PAGE and Coomassie blue staining

储存溶液:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

别名:1200013A08Rik; 1700095D18Rik; AI131686; Asp3; Dicam