1) Cat. No.: TRC-A575450; 2) Chemical Name: Aloisine A RP107; 3) CAS No.: 496864-16-5; 4) Mol. Formula: C16H17N3O; 5) Mol. Weight: 267.33; 6) Packing Size: 10mg / 100mg; 7) Appearence: Yellow solid; 8) Application Notes: A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively).  Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3, respectively), and c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).; 9) Synonym: RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol; ; 10) Solubility: DMSO, Methanol; 11) Storage condition: -20C Freezer; 12) References: Mattey, Y., et al.: J. Med. Chem., 46, 222 (2003), Noel, S., et al.: J. Pharmacol. Exp. Ther., 319, 349 (2006), Mitsuhashi, M., et al.: Pharm. Res., 25, 1116 (2008),