67kDa Laminin Receptor Mouse Monoclonal Antibody [Clone ID: LBI1G3]
产品名称: 67kDa Laminin Receptor Mouse Monoclonal Antibody [Clone ID: LBI1G3]
英文名称: 67kDa Laminin Receptor Mouse Monoclonal Antibody [Clone ID: LBI1G3]
产品编号: AMM20238VCF
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: WB 1:500~2000, IHC 1:2000
安诺伦(北京)生物科技有限公司
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- 地址 : 北京大兴经济技术开发区天骥智谷35A
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别名:37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA 产品概述:Carrier-free (BSA/glycerol-free) RPSA mouse monoclonal antibody,clone LBI1G3 总结:Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]