PCSK5 Rabbit pAb (APR25840N)
产品名称: PCSK5 Rabbit pAb (APR25840N)
英文名称: PCSK5 Rabbit pAb (APR25840N)
产品编号: APR25840N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围:
安诺伦(北京)生物科技有限公司
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分子量:Calculated MW: 101kDa/206kDa Observed MW: 102kDa 细胞定位:Endomembrane system, Secreted, Single-pass type I membrane protein 稀释方法:WB 1:500 - 1:2000 总结:This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B).