TLR3 Rabbit pAb (APR18641N)
产品名称: TLR3 Rabbit pAb (APR18641N)
英文名称: TLR3 Rabbit pAb (APR18641N)
产品编号: APR18641N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: WB (Mus musculus)
安诺伦(北京)生物科技有限公司
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分子量:Calculated MW: 72kDa/103kDa Observed MW: 104KDa 细胞定位:Early endosome, Endoplasmic reticulum membrane, Endosome membrane, Single-pass type I membrane protein 稀释方法:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 总结:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.