TLR3 Rabbit pAb (APR18641N)-抗体-抗体-生物在线
安诺伦(北京)生物科技有限公司
TLR3 Rabbit pAb (APR18641N)

TLR3 Rabbit pAb (APR18641N)

商家询价

产品名称: TLR3 Rabbit pAb (APR18641N)

英文名称: TLR3 Rabbit pAb (APR18641N)

产品编号: APR18641N

产品价格: null

产品产地: 美国

品牌商标: Leading Biology

更新时间: null

使用范围: WB (Mus musculus)

安诺伦(北京)生物科技有限公司
  • 联系人 :
  • 地址 : 北京大兴经济技术开发区天骥智谷35A
  • 邮编 :
  • 所在区域 : 北京
  • 电话 : 189****2642 点击查看
  • 传真 : 点击查看
  • 邮箱 : 3359689365@qq.com

分子量:Calculated MW: 72kDa/103kDa
Observed MW: 104KDa

细胞定位:Early endosome, Endoplasmic reticulum membrane, Endosome membrane, Single-pass type I membrane protein

稀释方法:WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200

总结:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.