[KO Validated] HIF1AN/FIH1 Rabbit mAb (AMR12812N)
产品名称: [KO Validated] HIF1AN/FIH1 Rabbit mAb (AMR12812N)
英文名称: [KO Validated] HIF1AN/FIH1 Rabbit mAb (AMR12812N)
产品编号: AMR12812N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围:
安诺伦(北京)生物科技有限公司
- 联系人 :
- 地址 : 北京大兴经济技术开发区天骥智谷35A
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- 所在区域 : 北京
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分子量:Calculated MW: 40kDa Observed MW: 40kDa 细胞定位:Cytoplasm, Nucleus, perinuclear region 稀释方法:WB 1:500 - 1:2000 总结:Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD. Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.